Avanafil

Avanafil

Assay: 99% min.

CAS: 330784-47-9

Molecular Formula:C23H26ClN7O3
 
Molecular Weight:483.9506

Molecular Structure:
 
Character: White to Off-White Cyrstalline Solid.

Usage: Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.

Categories: Active Pharmaceutical Ingredients; Cnbio; Erectile Dysfunction; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; API's.

Uses: it is a development of phosphodiesterase 5 inhibitor, for the treatment of male sexual dysfunction, at present in the United States, the European Union and Japan has completed phase II clinical trials, phase III clinical trial is going to start. The product is developed by the Japanese side pharmaceutical company and VIVUS company. In addition to oral dosage forms, VIVUS is also developing Avanafil's urinary tract to pharmaceutical type, for patients with no response to oral dosage forms. Avanafil is a potent and highly selective phosphodiesterase 5 inhibitor, in vitro experiments found than sildenafil on phosphodiesterase 5 more selective. The compounds of other phosphodiesterase affinity is weak and effect of adenosine receptors decreased, showed that avanafil cardiovascular effects should be than sildenafil weak. Pre clinical studies have demonstrated that organic nitrate and avanafil drugs combined use of its on blood pressure to reduce was significantly lower in the sildenafil and nitrates drugs in the same clothes. And avanafil on the inhibition of phosphodiesterase 6 is very weak, the visual impairment caused by the enzyme inhibition may and other phosphodiesterase type 5 inhibitors.
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